KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Lin Song; Shi Tang; Xiaolei Han; Ziying Jiang; Lingling Dong; Cuicui Liu; Xiaoyan Liang; Jixin Dong; Chengxuan Qiu; Yongxiang Wang; Yifeng Du

doi:10.1038/s41467-019-09720-x

Nature Communications (Apr 2019)

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Lin Song,
Shi Tang,
Xiaolei Han,
Ziying Jiang,
Lingling Dong,
Cuicui Liu,
Xiaoyan Liang,
Jixin Dong,
Chengxuan Qiu,
Yongxiang Wang,
Yifeng Du

Affiliations

Lin Song: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Shi Tang: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Xiaolei Han: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Ziying Jiang: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Lingling Dong: Department of Neurology, Dongying People’s Hospital
Cuicui Liu: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Xiaoyan Liang: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Jixin Dong: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center
Chengxuan Qiu: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Yongxiang Wang: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University
Yifeng Du: Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University

DOI: https://doi.org/10.1038/s41467-019-09720-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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