Frontiers in Physiology (Aug 2020)
Distinguishing Epileptiform Discharges From Normal Electroencephalograms Using Adaptive Fractal and Network Analysis: A Clinical Perspective
Abstract
Epilepsy is one of the most common disorders of the brain. Clinically, to corroborate an epileptic seizure-like symptom and to find the seizure localization, electroencephalogram (EEG) data are often visually examined by a clinical doctor to detect the presence of epileptiform discharges. Epileptiform discharges are transient waveforms lasting for several tens to hundreds of milliseconds and are mainly divided into seven types. It is important to develop systematic approaches to accurately distinguish these waveforms from normal control ones. This is a difficult task if one wishes to develop first principle rather than black-box based approaches, since clinically used scalp EEGs usually contain a lot of noise and artifacts. To solve this problem, we analyzed 640 multi-channel EEG segments, each 4s long. Among these segments, 540 are short epileptiform discharges, and 100 are from healthy controls. We have proposed two approaches for distinguishing epileptiform discharges from normal EEGs. The first method is based on Signal Range and EEGs' long range correlation properties characterized by the Hurst parameter H extracted by applying adaptive fractal analysis (AFA), which can also maximally suppress the effects of noise and various kinds of artifacts. Our second method is based on networks constructed from three aspects of the scalp EEG signals, the Signal Range, the energy of the alpha wave component, and EEG's long range correlation properties. The networks are further analyzed using singular value decomposition (SVD). The square of the first singular value from SVD is used to construct features to distinguish epileptiform discharges from normal controls. Using Random Forest Classifier (RF), our approaches can achieve very high accuracy in distinguishing epileptiform discharges from normal control ones, and thus are very promising to be used clinically. The network-based approach is also used to infer the localizations of each type of epileptiform discharges, and it is found that the sub-networks representing the most likely location of each type of epileptiform discharges are different among the seven types of epileptiform discharges.
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