Nature Communications (Nov 2017)
The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
- Federica Fusella,
- Laura Seclì,
- Elena Busso,
- Anna Krepelova,
- Enrico Moiso,
- Stefania Rocca,
- Laura Conti,
- Laura Annaratone,
- Cristina Rubinetto,
- Maurizia Mello-Grand,
- Vijay Singh,
- Giovanna Chiorino,
- Lorenzo Silengo,
- Fiorella Altruda,
- Emilia Turco,
- Alessandro Morotti,
- Salvatore Oliviero,
- Isabella Castellano,
- Federica Cavallo,
- Paolo Provero,
- Guido Tarone,
- Mara Brancaccio
Affiliations
- Federica Fusella
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Laura Seclì
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Elena Busso
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Anna Krepelova
- Department of Life Sciences and Systems Biology, University of Torino
- Enrico Moiso
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Stefania Rocca
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Laura Conti
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Laura Annaratone
- Department of Medical Sciences, University of Torino
- Cristina Rubinetto
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Maurizia Mello-Grand
- Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia
- Vijay Singh
- Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia
- Giovanna Chiorino
- Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia
- Lorenzo Silengo
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Fiorella Altruda
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Emilia Turco
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Alessandro Morotti
- Department of Clinical and Biological Sciences, University of Torino
- Salvatore Oliviero
- Department of Life Sciences and Systems Biology, University of Torino
- Isabella Castellano
- Department of Medical Sciences, University of Torino
- Federica Cavallo
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Paolo Provero
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Guido Tarone
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Mara Brancaccio
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- DOI
- https://doi.org/10.1038/s41467-017-01829-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recruitment.
