Nature Communications (Nov 2017)
Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA
- Yuan Tian,
- Mariana Babor,
- Jerome Lane,
- Veronique Schulten,
- Veena S. Patil,
- Grégory Seumois,
- Sandy L. Rosales,
- Zheng Fu,
- Gaelle Picarda,
- Julie Burel,
- Jose Zapardiel-Gonzalo,
- Rashika N. Tennekoon,
- Aruna D. De Silva,
- Sunil Premawansa,
- Gayani Premawansa,
- Ananda Wijewickrama,
- Jason A. Greenbaum,
- Pandurangan Vijayanand,
- Daniela Weiskopf,
- Alessandro Sette,
- Bjoern Peters
Affiliations
- Yuan Tian
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Mariana Babor
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Jerome Lane
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Veronique Schulten
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Veena S. Patil
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Grégory Seumois
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Sandy L. Rosales
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Zheng Fu
- Bioinformatics Core Facility, La Jolla Institute for Allergy and Immunology
- Gaelle Picarda
- Division of Immune Regulation, La Jolla Institute for Allergy and Immunology
- Julie Burel
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Jose Zapardiel-Gonzalo
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Rashika N. Tennekoon
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Aruna D. De Silva
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Sunil Premawansa
- Department of Zoology and Environment Sciences, Science Faculty, University of Colombo
- Gayani Premawansa
- North Colombo Teaching Hospital
- Ananda Wijewickrama
- National Institute of Infectious Diseases
- Jason A. Greenbaum
- Bioinformatics Core Facility, La Jolla Institute for Allergy and Immunology
- Pandurangan Vijayanand
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Daniela Weiskopf
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Alessandro Sette
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Bjoern Peters
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- DOI
- https://doi.org/10.1038/s41467-017-01728-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Memory T cells are essential for combating recurring infection by promoting prompt and effective immune responses. Here the authors show, via system biology approaches, that human CD4 memory T cells contains a CD45RA-rexpressing pool that can be further subsetted by the expression of GPR56 for distinct functionalities.
