International Journal of General Medicine (Nov 2021)

Association of Admission Blood Glucose Level with All-Cause Mortality According to Age in Patients with Community Acquired Pneumonia

  • Shen Y,
  • Xu X,
  • Meng S,
  • Qin M,
  • Li H,
  • Chu D,
  • Zheng C

Journal volume & issue
Vol. Volume 14
pp. 7775 – 7781

Abstract

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Yejing Shen,1,2 Xiaowen Xu,2 Siming Meng,2 Meng Qin,2 Hailing Li,2 Dejie Chu,1 Cuixia Zheng2 1Department of Respiratory Medicine, Shanghai Eighth People’s Hospital, Shanghai, 200235, People’s Republic of China; 2Department of Respiratory Medicine, Yangpu Hospital Affiliated to Tongji University, Shanghai, 200090, People’s Republic of ChinaCorrespondence: Dejie ChuDepartment of Respiratory Medicine, Shanghai Eighth People’s Hospital, 8 Caobao Road, Shanghai, 200235, People’s Republic of ChinaEmail [email protected] ZhengDepartment of Respiratory Medicine, Yangpu Hospital Affiliated to Tongji University, 450 Tengyue Road, Shanghai, 200090, People’s Republic of ChinaEmail [email protected]: To assess the impact of blood glucose levels on the prognosis of patients with community-acquired pneumonia (CAP) who were elderly or middle-aged.Methods: From January 1, 2018, to December 31, 2020, patients with CAP (≥ 45 years) were retrospectively enrolled in this observational study. They were stratified by age (45– 64 or ≥ 65 years) and blood glucose level (≥ 11.1 or < 11.1 mmol/l). The effect of admission blood glucose on 28-day mortality was assessed with the Cox proportional hazards model, adjusted for demographic factors and comorbidity.Results: Among 1656 patients with CAP, increased blood glucose (HR=2.08, 95% CI: 1.38– 3.49; P< 0.01) and advanced age (HR=2.76, 95% CI: 1.65– 3.77; P< 0.01) were significantly associated with a higher risk of 28-day mortality, after controlling for potential confounding factors. The strength of the association of blood glucose level with 28-day mortality decreased with age (P=0.01 for the interaction) as the adjusted HRs for death were 4.48 (95% CI: 1.40– 13.65; P< 0.01) for middle-age patients 45– 64 years and 1.52 (95% CI: 1.09– 2.17; P=0.05) for elderly patients ≥ 65 years.Conclusion: The association of blood glucose level upon admission for CAP with all-cause mortality was stronger at younger ages.Keywords: age, community-acquired pneumonia, hyperglycemia, mortality, prognosis

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