The correlations data between whether liposomes are coated or not and flatfish's (paralichthys olivaceus) Streptococcus parauberis antibody formation ability and survival rates
Eun Sol Jo,
Hyun-Ja Han,
Deok Chan Lee,
Kwang Il Kim,
Mi Young Cho,
Sung-Hee Jung,
Chan-Il Park,
Andre Kim
Affiliations
Eun Sol Jo
Natural Science Institute, Silla University, Busan 46958, Republic of Korea
Hyun-Ja Han
Pathology Research Division, Aquaculture Research Department, National Institute of Fisheris Sicience, Busan 46083, Republic of Korea
Deok Chan Lee
Pathology Research Division, Aquaculture Research Department, National Institute of Fisheris Sicience, Busan 46083, Republic of Korea
Kwang Il Kim
Pathology Research Division, Aquaculture Research Department, National Institute of Fisheris Sicience, Busan 46083, Republic of Korea
Mi Young Cho
Pathology Research Division, Aquaculture Research Department, National Institute of Fisheris Sicience, Busan 46083, Republic of Korea
Sung-Hee Jung
Pathology Research Division, Aquaculture Research Department, National Institute of Fisheris Sicience, Busan 46083, Republic of Korea
Chan-Il Park
Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 455, Tongyeong 650-160, Republic of Korea
Andre Kim
Department of Pharmaceutical Engineering Division of Bioindustry, College of Medical and Life Science Silla University, Busan 46958, Republic of Korea; Corresponding author.
Streptococcus parauberis is a known etiologic agent that causes damage leading to death in flatfish (paralichthys olivaceus). Liposomes were used to deliver streptococcal oral vaccines to the intestinal mucous membranes of paralichthys olivaceus. The liposomes were coated for stabilization, and stability was measured with high performance liquid chromatography (HPLC). The liposomes were stable until day nine and were orally administered to flatfish as a vaccine. The resultant antibody titers were analyzed. The titers resulting from the uncoated liposomes were highest two weeks after the oral administration, and those resulting from the coated liposomes were highest one week after boosting. In addition, the bacteria were subcutaneously injected to artificially infect flatfish and the survival rates and relative survival rates were analyzed. The coated liposomes were found to yield the highest survival rate.
