Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants

E. A. Plotnikova; V. O. Stramova; N. B. Morozova; A. D. Plyutinskaya; P. V. Ostroverkhov; M. A. Grin; A. F. Mironov; R. I. Yakubovskaya; A. D. Kaprin

doi:10.24931/2413-9432-2019-8-1-18-23

Biomedical Photonics (Apr 2019)

Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants

E. A. Plotnikova,
V. O. Stramova,
N. B. Morozova,
A. D. Plyutinskaya,
P. V. Ostroverkhov,
M. A. Grin,
A. F. Mironov,
R. I. Yakubovskaya,
A. D. Kaprin

Affiliations

E. A. Plotnikova: P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow
V. O. Stramova: P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow
N. B. Morozova: P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow
A. D. Plyutinskaya: P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow
P. V. Ostroverkhov: Federal State Budget Educational Institution of Higher Education “MIREA – Moscow Technological University”, Moscow
M. A. Grin: Federal State Budget Educational Institution of Higher Education “MIREA – Moscow Technological University”, Moscow
A. F. Mironov: Federal State Budget Educational Institution of Higher Education “MIREA – Moscow Technological University”, Moscow
R. I. Yakubovskaya: P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow
A. D. Kaprin: P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow

DOI: https://doi.org/10.24931/2413-9432-2019-8-1-18-23
Journal volume & issue: Vol. 8, no. 1
pp. 18 – 23

Abstract

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The aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) – O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax = 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Poloxamer 407, Emuxol 268) were obtained. Taking into account the physical and chemical parameters, the most potent micellar emulsion for injection was selected and characterized. The emulsion based on Kolliphor ELP remains stable for 4 months, with no changes in the fluorescence spectrum and absorption, as well as the particle diameter.

Published in Biomedical Photonics

ISSN: 2413-9432 (Print)
Publisher: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
Country of publisher: Russian Federation
LCC subjects: Medicine: Medicine (General): Medical technology
Website: http://www.pdt-journal.com/

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