Nature Communications (Nov 2022)
Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter
- Tim Schulte,
- Antonio Chaves-Sanjuan,
- Giulia Mazzini,
- Valentina Speranzini,
- Francesca Lavatelli,
- Filippo Ferri,
- Carlo Palizzotto,
- Maria Mazza,
- Paolo Milani,
- Mario Nuvolone,
- Anne-Cathrine Vogt,
- Monique Vogel,
- Giovanni Palladini,
- Giampaolo Merlini,
- Martino Bolognesi,
- Silvia Ferro,
- Eric Zini,
- Stefano Ricagno
Affiliations
- Tim Schulte
- Institute of Molecular and Translational Cardiology, IRCCS Policlinico San Donato
- Antonio Chaves-Sanjuan
- Department of Biosciences, Università degli Studi di Milano
- Giulia Mazzini
- Department of Molecular Medicine, University of Pavia
- Valentina Speranzini
- Department of Biosciences, Università degli Studi di Milano
- Francesca Lavatelli
- Department of Molecular Medicine, University of Pavia
- Filippo Ferri
- AniCura Istituto Veterinario Novara
- Carlo Palizzotto
- AniCura Istituto Veterinario Novara
- Maria Mazza
- Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, S.C. Diagnostica Specialistica
- Paolo Milani
- Department of Molecular Medicine, University of Pavia
- Mario Nuvolone
- Department of Molecular Medicine, University of Pavia
- Anne-Cathrine Vogt
- Department for BioMedical Research (DBMR), University of Bern
- Monique Vogel
- Department for BioMedical Research (DBMR), University of Bern
- Giovanni Palladini
- Department of Molecular Medicine, University of Pavia
- Giampaolo Merlini
- Department of Molecular Medicine, University of Pavia
- Martino Bolognesi
- Department of Biosciences, Università degli Studi di Milano
- Silvia Ferro
- Department of Comparative Biomedicine and Food Sciences, University of Padova
- Eric Zini
- AniCura Istituto Veterinario Novara
- Stefano Ricagno
- Institute of Molecular and Translational Cardiology, IRCCS Policlinico San Donato
- DOI
- https://doi.org/10.1038/s41467-022-34743-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Here, the authors report the cryoEM structure of AA amyloid from a cat shelter with extreme disease prevalence and reveal the feline-specific sequence insert in the fibril core. The sequence is 99% identical to AA amyloid from cheetah with reported prion-like transmission in zoos.
