Nature Communications (Jul 2020)
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
- Sara De Biasi,
- Marianna Meschiari,
- Lara Gibellini,
- Caterina Bellinazzi,
- Rebecca Borella,
- Lucia Fidanza,
- Licia Gozzi,
- Anna Iannone,
- Domenico Lo Tartaro,
- Marco Mattioli,
- Annamaria Paolini,
- Marianna Menozzi,
- Jovana Milić,
- Giacomo Franceschi,
- Riccardo Fantini,
- Roberto Tonelli,
- Marco Sita,
- Mario Sarti,
- Tommaso Trenti,
- Lucio Brugioni,
- Luca Cicchetti,
- Fabio Facchinetti,
- Antonello Pietrangelo,
- Enrico Clini,
- Massimo Girardis,
- Giovanni Guaraldi,
- Cristina Mussini,
- Andrea Cossarizza
Affiliations
- Sara De Biasi
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Marianna Meschiari
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Lara Gibellini
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Caterina Bellinazzi
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Rebecca Borella
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Lucia Fidanza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Licia Gozzi
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Anna Iannone
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Domenico Lo Tartaro
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Marco Mattioli
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Annamaria Paolini
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Marianna Menozzi
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Jovana Milić
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Giacomo Franceschi
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Riccardo Fantini
- Respiratory Diseases Unit, AOU Policlinico and University of Modena and Reggio Emilia
- Roberto Tonelli
- Respiratory Diseases Unit, AOU Policlinico and University of Modena and Reggio Emilia
- Marco Sita
- Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia
- Mario Sarti
- Clinical Microbiology Unit, AOU Policlinico
- Tommaso Trenti
- Clinical Microbiology Unit, AOU Policlinico
- Lucio Brugioni
- Emergency Department, MIAC, AOU Policlinico
- Luca Cicchetti
- Labospace, via Apelle 41
- Fabio Facchinetti
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Antonello Pietrangelo
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Enrico Clini
- Respiratory Diseases Unit, AOU Policlinico and University of Modena and Reggio Emilia
- Massimo Girardis
- Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia
- Giovanni Guaraldi
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Cristina Mussini
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Andrea Cossarizza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17292-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
COVID-19 is a serious pandemic threat to public health, but insights on the pathophysiological and immunological conditions are only emerging. Here the authors use multi-color flow cytometry to characterize CD4+ and CD8+ T cells in peripheral blood from 39 COVID-19 patients in Italy to report altered T cell activation, function and polarization.
