Nature Communications (May 2017)
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
- Lucia Campos Carrascosa,
- Matthias Klein,
- Yohko Kitagawa,
- Christina Lückel,
- Federico Marini,
- Anika König,
- Anna Guralnik,
- Hartmann Raifer,
- Stefanie Hagner-Benes,
- Diana Rädler,
- Andreas Böck,
- Cholho Kang,
- Michael Lohoff,
- Holger Garn,
- Bianca Schaub,
- Friederike Berberich-Siebelt,
- Shimon Sakaguchi,
- Tobias Bopp,
- Magdalena Huber
Affiliations
- Lucia Campos Carrascosa
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- Matthias Klein
- Institute for Immunology, University Medical Center Mainz
- Yohko Kitagawa
- Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Christina Lückel
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- Federico Marini
- Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz
- Anika König
- Institute of Pathology, University of Würzburg
- Anna Guralnik
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- Hartmann Raifer
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- Stefanie Hagner-Benes
- Institute for Laboratory Medicine and Pathobiochemistry, University of Marburg
- Diana Rädler
- Department of Pulmonary and Allergy, University Childrens’s Hospital Munich, LMU Munich
- Andreas Böck
- Department of Pulmonary and Allergy, University Childrens’s Hospital Munich, LMU Munich
- Cholho Kang
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- Michael Lohoff
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- Holger Garn
- Institute for Laboratory Medicine and Pathobiochemistry, University of Marburg
- Bianca Schaub
- Department of Pulmonary and Allergy, University Childrens’s Hospital Munich, LMU Munich
- Friederike Berberich-Siebelt
- Institute of Pathology, University of Würzburg
- Shimon Sakaguchi
- Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Tobias Bopp
- Institute for Immunology, University Medical Center Mainz
- Magdalena Huber
- Institute for Medical Microbiology and Hospital Hygiene, University of Marburg
- DOI
- https://doi.org/10.1038/ncomms15366
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 forIl9promoter binding and skewing these cells towards a Th1 phenotype, an effect that reduces asthmatic inflammation in mice.
