HIRA stabilizes skeletal muscle lineage identity

Joana Esteves de Lima; Reem Bou Akar; Léo Machado; Yuefeng Li; Bernadette Drayton-Libotte; F. Jeffrey Dilworth; Frédéric Relaix

doi:10.1038/s41467-021-23775-9

Nature Communications (Jun 2021)

HIRA stabilizes skeletal muscle lineage identity

Joana Esteves de Lima,
Reem Bou Akar,
Léo Machado,
Yuefeng Li,
Bernadette Drayton-Libotte,
F. Jeffrey Dilworth,
Frédéric Relaix

Affiliations

Joana Esteves de Lima: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
Reem Bou Akar: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
Léo Machado: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
Yuefeng Li: Department of Cellular and Molecular Medicine, University of Ottawa
Bernadette Drayton-Libotte: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
F. Jeffrey Dilworth: Department of Cellular and Molecular Medicine, University of Ottawa
Frédéric Relaix: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB

DOI: https://doi.org/10.1038/s41467-021-23775-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The epigenetic mechanisms coordinating the maintenance of adult cellular lineages remain poorly understood. Here the authors demonstrate that HIRA, a H3.3 histone chaperone, establishes the chromatin landscape required for skeletal muscle cell identity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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