Cardiovascular Diabetology (Sep 2012)

Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects

  • Dagvasumberel Munkhbaatar,
  • Shimabukuro Michio,
  • Nishiuchi Takeshi,
  • Ueno Junji,
  • Takao Shoichiro,
  • Fukuda Daiju,
  • Hirata Yoichiro,
  • Kurobe Hirotsugu,
  • Soeki Takeshi,
  • Iwase Takashi,
  • Kusunose Kenya,
  • Niki Toshiyuki,
  • Yamaguchi Koji,
  • Taketani Yoshio,
  • Yagi Shusuke,
  • Tomita Noriko,
  • Yamada Hirotsugu,
  • Wakatsuki Tetsuzo,
  • Harada Masafumi,
  • Kitagawa Tetsuya,
  • Sata Masataka

DOI
https://doi.org/10.1186/1475-2840-11-106
Journal volume & issue
Vol. 11, no. 1
p. 106

Abstract

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Abstract Background Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. Methods The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. Results EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p 3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p Conclusions Increased EATV is strongly associated with coronary atherosclerosis in men.

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