Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
Ricardo Escarcena,
Jonathan Perez-Meseguer,
Esther del Olmo,
Blanca Alanis-Garza,
Elvira Garza-González,
Ricardo Salazar-Aranda,
Noemí Waksman de Torres
Affiliations
Ricardo Escarcena
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain
Jonathan Perez-Meseguer
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico
Esther del Olmo
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain
Blanca Alanis-Garza
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico
Elvira Garza-González
Servicio de Gastroenterología y Departamento de Patología Clínica, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo Leon, Av. Madero y Gonzalitos S/N, Mitras Centro, Monterrey, NL 64220, Mexico
Ricardo Salazar-Aranda
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico
Noemí Waksman de Torres
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico
Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol.
