Nature Communications (Aug 2020)
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
- Elisabeth Jäger,
- Supriya Murthy,
- Caroline Schmidt,
- Magdalena Hahn,
- Sarah Strobel,
- Anna Peters,
- Claudia Stäubert,
- Pelin Sungur,
- Tom Venus,
- Mandy Geisler,
- Veselina Radusheva,
- Stefanie Raps,
- Kathrin Rothe,
- Roger Scholz,
- Sebastian Jung,
- Sylke Wagner,
- Matthias Pierer,
- Olga Seifert,
- Wenhan Chang,
- Irina Estrela-Lopis,
- Nora Raulien,
- Knut Krohn,
- Norbert Sträter,
- Stephanie Hoeppener,
- Torsten Schöneberg,
- Manuela Rossol,
- Ulf Wagner
Affiliations
- Elisabeth Jäger
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Supriya Murthy
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Caroline Schmidt
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Magdalena Hahn
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Sarah Strobel
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Anna Peters
- Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University
- Claudia Stäubert
- Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University
- Pelin Sungur
- Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena
- Tom Venus
- Institute for Medical Physics and Biophysics, Leipzig University
- Mandy Geisler
- Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University
- Veselina Radusheva
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Stefanie Raps
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Kathrin Rothe
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Roger Scholz
- Department of Orthopaedic, Trauma and Plastic Surgery, Leipzig University
- Sebastian Jung
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Sylke Wagner
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Matthias Pierer
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Olga Seifert
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Wenhan Chang
- UCSF Department of Veterans Affairs Medical Center
- Irina Estrela-Lopis
- Institute for Medical Physics and Biophysics, Leipzig University
- Nora Raulien
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Knut Krohn
- DNA Core Unit Leipzig
- Norbert Sträter
- Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University
- Stephanie Hoeppener
- Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena
- Torsten Schöneberg
- Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University
- Manuela Rossol
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- Ulf Wagner
- Department of Internal Medicine, Division of Rheumatology, Leipzig University
- DOI
- https://doi.org/10.1038/s41467-020-17749-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and this pathway might be critical to inflammatory conditions.
