Nature Communications (Jun 2020)
Human norovirus targets enteroendocrine epithelial cells in the small intestine
- Kim Y. Green,
- Stuart S. Kaufman,
- Bianca M. Nagata,
- Natthawan Chaimongkol,
- Daniel Y. Kim,
- Eric A. Levenson,
- Christine M. Tin,
- Allison Behrle Yardley,
- Jordan A. Johnson,
- Ana Beatriz F. Barletta,
- Khalid M. Khan,
- Nada A. Yazigi,
- Sukanya Subramanian,
- Sangeetha R. Moturi,
- Thomas M. Fishbein,
- Ian N. Moore,
- Stanislav V. Sosnovtsev
Affiliations
- Kim Y. Green
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Stuart S. Kaufman
- MedStar Georgetown Transplant Institute and Georgetown University Medical Center
- Bianca M. Nagata
- Infectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Natthawan Chaimongkol
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Daniel Y. Kim
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Eric A. Levenson
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Christine M. Tin
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Allison Behrle Yardley
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jordan A. Johnson
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Ana Beatriz F. Barletta
- Mosquito Immunity and Vector Competence Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Khalid M. Khan
- MedStar Georgetown Transplant Institute and Georgetown University Medical Center
- Nada A. Yazigi
- MedStar Georgetown Transplant Institute and Georgetown University Medical Center
- Sukanya Subramanian
- MedStar Georgetown Transplant Institute and Georgetown University Medical Center
- Sangeetha R. Moturi
- MedStar Georgetown Transplant Institute and Georgetown University Medical Center
- Thomas M. Fishbein
- MedStar Georgetown Transplant Institute and Georgetown University Medical Center
- Ian N. Moore
- Infectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Stanislav V. Sosnovtsev
- Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-020-16491-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.
