FEATURES OF THE LARGE INTESTINE MICROFLORA OF CHILDREN – DONOR LIVER TRANSPLANT RECIPIENTS

N. I. Gabrielyan; E. M. Gorskaya; O. M. Tsirulnikova; T. S. Spirina; L. Y. Romashkina

doi:10.15825/1995-1191-2013-4-40-46

Вестник трансплантологии и искусственных органов (May 2014)

FEATURES OF THE LARGE INTESTINE MICROFLORA OF CHILDREN – DONOR LIVER TRANSPLANT RECIPIENTS

N. I. Gabrielyan,
E. M. Gorskaya,
O. M. Tsirulnikova,
T. S. Spirina,
L. Y. Romashkina

Affiliations

N. I. Gabrielyan: Department endotoxicosis and septic complications (Head – M.D. N.I. Gabrielyan) Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
E. M. Gorskaya: Department endotoxicosis and septic complications (Head – M.D. N.I. Gabrielyan) Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
O. M. Tsirulnikova: Department of Clinical Transplantation (Head – prof. Y.G. Moysyuk) at same center Chair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation
T. S. Spirina: Department endotoxicosis and septic complications (Head – M.D. N.I. Gabrielyan) Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
L. Y. Romashkina: Department endotoxicosis and septic complications (Head – M.D. N.I. Gabrielyan) Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation

DOI: https://doi.org/10.15825/1995-1191-2013-4-40-46
Journal volume & issue: Vol. 15, no. 4
pp. 40 – 46

Abstract

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Aim. The study microecology of the large intestine of children with cirrhosis before transplantation of the share liver. Materials and methods. Studied the flora of the colon 157 children of 1 to 17 years admitted to hospital for liver transplantation fragment from a related donor. Identification was carried out using microbial panels BD Crystal and databases BBL Crystal MIND. Methicillin-resistant staphylococci were determined by their sensiti- vity to oxacillin and cefoxitin. Beta-lactamase activity was tested using discs with ceftazidime and ceftazidime/ clavulanic acid. Results. Microecological revealed deep irregularities in the large intestine transplantation in children up lobe of the liver on a spectrum and composition of the microflora. Among the resident microflora decreased levels of bifidobacteria, lactobacilli and coliform bacteria, especially in children under one year. A sig- nificant portion of the children surveyed (over 60–70%) had an increase of frequency of finding stateally bacteria, especially Klebsiella and enterobacteria in third children – non-fermenting bacteria – Pseudomonas and Acine- tobacter spp. Revealed the spread of strains of gram-negative bacteria with extended-spectrum betalaktamaz.Conclusion. Expressed microecological violations in the large intestine in children with higher levels of bac- teria are conditionally risk factor reeks of infectious complications in the postoperative period and require are complex tools to assist in eliminatsii.s given antibiotic resistance of bacteria.

microecology of the intestine, liver children share transplantation

Published in Вестник трансплантологии и искусственных органов

ISSN: 1995-1191 (Print)
Publisher: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
Country of publisher: Russian Federation
LCC subjects: Medicine: Surgery
Website: http://journal.transpl.ru/

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