Inhibition of MYC by the SMARCB1 tumor suppressor

April M. Weissmiller; Jing Wang; Shelly L. Lorey; Gregory C. Howard; Ernest Martinez; Qi Liu; William P. Tansey

doi:10.1038/s41467-019-10022-5

Nature Communications (May 2019)

Inhibition of MYC by the SMARCB1 tumor suppressor

April M. Weissmiller,
Jing Wang,
Shelly L. Lorey,
Gregory C. Howard,
Ernest Martinez,
Qi Liu,
William P. Tansey

Affiliations

April M. Weissmiller: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine
Jing Wang: Center for Quantitative Sciences, Vanderbilt University School of Medicine
Shelly L. Lorey: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine
Gregory C. Howard: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine
Ernest Martinez: Department of Biochemistry, University of California at Riverside
Qi Liu: Center for Quantitative Sciences, Vanderbilt University School of Medicine
William P. Tansey: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-10022-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of RNA polymerase pause release at MYC target genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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