Nature Communications (Nov 2016)
In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
- Xia Wu,
- Juan D. Chavez,
- Devin K. Schweppe,
- Chunxiang Zheng,
- Chad R. Weisbrod,
- Jimmy K. Eng,
- Ananya Murali,
- Samuel A. Lee,
- Elizabeth Ramage,
- Larry A. Gallagher,
- Hemantha D. Kulasekara,
- Mauna E. Edrozo,
- Cassandra N. Kamischke,
- Mitchell J. Brittnacher,
- Samuel I. Miller,
- Pradeep K. Singh,
- Colin Manoil,
- James E. Bruce
Affiliations
- Xia Wu
- Department of Genome Sciences, University of Washington
- Juan D. Chavez
- Department of Genome Sciences, University of Washington
- Devin K. Schweppe
- Department of Genome Sciences, University of Washington
- Chunxiang Zheng
- Department of Chemistry, University of Washington
- Chad R. Weisbrod
- Department of Genome Sciences, University of Washington
- Jimmy K. Eng
- Department of Genome Sciences, University of Washington
- Ananya Murali
- Department of Genome Sciences, University of Washington
- Samuel A. Lee
- Department of Genome Sciences, University of Washington
- Elizabeth Ramage
- Department of Genome Sciences, University of Washington
- Larry A. Gallagher
- Department of Genome Sciences, University of Washington
- Hemantha D. Kulasekara
- Department of Microbiology, University of Washington
- Mauna E. Edrozo
- Department of Microbiology, University of Washington
- Cassandra N. Kamischke
- Department of Microbiology, University of Washington
- Mitchell J. Brittnacher
- Department of Microbiology, University of Washington
- Samuel I. Miller
- Department of Genome Sciences, University of Washington
- Pradeep K. Singh
- Department of Microbiology, University of Washington
- Colin Manoil
- Department of Genome Sciences, University of Washington
- James E. Bruce
- Department of Genome Sciences, University of Washington
- DOI
- https://doi.org/10.1038/ncomms13414
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of porin-localised antibiotic inactivation.
