Nature Communications (Feb 2018)
The effects of death and post-mortem cold ischemia on human tissue transcriptomes
- Pedro G. Ferreira,
- Manuel Muñoz-Aguirre,
- Ferran Reverter,
- Caio P. Sá Godinho,
- Abel Sousa,
- Alicia Amadoz,
- Reza Sodaei,
- Marta R. Hidalgo,
- Dmitri Pervouchine,
- Jose Carbonell-Caballero,
- Ramil Nurtdinov,
- Alessandra Breschi,
- Raziel Amador,
- Patrícia Oliveira,
- Cankut Çubuk,
- João Curado,
- François Aguet,
- Carla Oliveira,
- Joaquin Dopazo,
- Michael Sammeth,
- Kristin G. Ardlie,
- Roderic Guigó
Affiliations
- Pedro G. Ferreira
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Manuel Muñoz-Aguirre
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Ferran Reverter
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Caio P. Sá Godinho
- Institute of Biophysics Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro (UFRJ)
- Abel Sousa
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Alicia Amadoz
- Department of Bioinformatics, Igenomix S.A
- Reza Sodaei
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Marta R. Hidalgo
- Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocio
- Dmitri Pervouchine
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Jose Carbonell-Caballero
- Chromatin and Gene expression Lab, Gene Regulation, Stem Cells and Cancer Program, Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology, PRBB
- Ramil Nurtdinov
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Alessandra Breschi
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Raziel Amador
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Patrícia Oliveira
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Cankut Çubuk
- Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocio
- João Curado
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- François Aguet
- The Broad Institute of MIT and Harvard
- Carla Oliveira
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Joaquin Dopazo
- Department of Bioinformatics, Igenomix S.A
- Michael Sammeth
- Institute of Biophysics Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro (UFRJ)
- Kristin G. Ardlie
- The Broad Institute of MIT and Harvard
- Roderic Guigó
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- DOI
- https://doi.org/10.1038/s41467-017-02772-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
RNA levels in post-mortem tissue can differ greatly from those before death. Studying the effect of post-mortem interval on the transcriptome in 36 human tissues, Ferreira et al. find that the response to death is largely tissue-specific and develop a model to predict time since death based on RNA data.
