Nature Communications (Dec 2017)
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1
- Metehan Cifdaloz,
- Lisa Osterloh,
- Osvaldo Graña,
- Erica Riveiro-Falkenbach,
- Pilar Ximénez-Embún,
- Javier Muñoz,
- Cristina Tejedo,
- Tonantzin G. Calvo,
- Panagiotis Karras,
- David Olmeda,
- Belén Miñana,
- Gonzalo Gómez-López,
- Estela Cañon,
- Eduardo Eyras,
- Haihong Guo,
- Ferdinand Kappes,
- Pablo L. Ortiz-Romero,
- Jose L. Rodríguez-Peralto,
- Diego Megías,
- Juan Valcárcel,
- María S. Soengas
Affiliations
- Metehan Cifdaloz
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- Lisa Osterloh
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- Osvaldo Graña
- Bioinformatics Unit, CNIO
- Erica Riveiro-Falkenbach
- Instituto de Investigación i+12, Hospital 12 de Octubre Medical School, Universidad Complutense
- Pilar Ximénez-Embún
- Proteomics Core Unit, CNIO
- Javier Muñoz
- Proteomics Core Unit, CNIO
- Cristina Tejedo
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- Tonantzin G. Calvo
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- Panagiotis Karras
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- David Olmeda
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- Belén Miñana
- Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology
- Gonzalo Gómez-López
- Bioinformatics Unit, CNIO
- Estela Cañon
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- Eduardo Eyras
- Department of Experimental and Health Sciences, Universidad Pompeu Fabra
- Haihong Guo
- Institute of Biochemistry and Molecular Biology; Medical School, RWTH Aachen University
- Ferdinand Kappes
- Institute of Biochemistry and Molecular Biology; Medical School, RWTH Aachen University
- Pablo L. Ortiz-Romero
- Instituto de Investigación i+12, Hospital 12 de Octubre Medical School, Universidad Complutense
- Jose L. Rodríguez-Peralto
- Instituto de Investigación i+12, Hospital 12 de Octubre Medical School, Universidad Complutense
- Diego Megías
- Confocal Microscopy Unit, (CNIO)
- Juan Valcárcel
- Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology
- María S. Soengas
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO)
- DOI
- https://doi.org/10.1038/s41467-017-02353-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors.
