Nature Communications (Apr 2018)
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
- Mina Ali,
- Ram Ajore,
- Anna-Karin Wihlborg,
- Abhishek Niroula,
- Bhairavi Swaminathan,
- Ellinor Johnsson,
- Owen W Stephens,
- Gareth Morgan,
- Tobias Meissner,
- Ingemar Turesson,
- Hartmut Goldschmidt,
- Ulf-Henrik Mellqvist,
- Urban Gullberg,
- Markus Hansson,
- Kari Hemminki,
- Hareth Nahi,
- Anders Waage,
- Niels Weinhold,
- Björn Nilsson
Affiliations
- Mina Ali
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Ram Ajore
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Anna-Karin Wihlborg
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Abhishek Niroula
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Bhairavi Swaminathan
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Ellinor Johnsson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Owen W Stephens
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Gareth Morgan
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Tobias Meissner
- Department of Molecular and Experimental Medicine, Avera Cancer Institute
- Ingemar Turesson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Hartmut Goldschmidt
- Department of Internal Medicine V, University of Heidelberg
- Ulf-Henrik Mellqvist
- Section of Hematology, South Elvsborg Hospital
- Urban Gullberg
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Markus Hansson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Kari Hemminki
- German Cancer Research Center
- Hareth Nahi
- Center for Hematology and Regenerative Medicine, Karolinska Institutet
- Anders Waage
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Niels Weinhold
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Björn Nilsson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- DOI
- https://doi.org/10.1038/s41467-018-04082-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors.
