Ukrainian Scientific Medical Youth Journal (Apr 2016)
CHANGES IN ACTIVITY OF DIFFERENT LINKS OF PLASMA HEMOSTASIS IN PATIENTS WITH HYPERTENSION AND CORONARY HEART DISEASE
Abstract
Purpose - to evaluate changes of procoagulant, anticoagulant and fibrinolytic links of the system of hemostasis in patients with hypertension and stable coronary artery disease. Materials and methods. We have examined 113 patients, of whom 38 patients with the diagnosis essential hypertension stage II (group 2) and 61 patients with essential hypertension stage II in combination with coronary heart disease (group 3). The control group consisted of 14 patients without hypertension and coronary heart disease, matched by age and sex with a group of 2 or Patients were evaluated hemostatic parameters: thrombin time, activated partial thromboplastin time, prothrombin index, soluble fibrin monomer complex, fibrinogen, protein C, antithrombin III of, time of XII- dependent fibrinolysis. Results. Patients on both study groups SFMC content significantly higher than the control group. The content of SFMC in the group of hypertensive patients exceeded the standard values of 2.4 times, and in patients with concomitant coronary heart disease of 3.01 times. The fibrinogen content in group 3 was 11% higher. There was a reduction of IPT in patients of group 2 at 4.8% compared with the control group, patients in the 3 group of 6.5% with no significant difference between groups. There was a decrease of AT III activity of 1.25 times and 1.19 times respectively in groups. Time of Xll-dependent fibrinolysis in hypertensive patients was 2.13 times longer than the standard values, and the combination of hypertension and CAD in 3.54 times as long as normal. Conclusions. For patients with hypertension and its combination with ischemic heart disease is characteristic increased blood clotting activity in the background suppression of the anticoagulant and fibrinolytic components of hemostasis. The largest contribution to the formation of thrombophilic changes in patients from both study groups belongs inhibition of fibrinolysis, which is more pronounced when combined hypertension and coronary heart disease.
