Nature Communications (Nov 2020)
Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
- Shidan Tosif,
- Melanie R. Neeland,
- Philip Sutton,
- Paul V. Licciardi,
- Sohinee Sarkar,
- Kevin J. Selva,
- Lien Anh Ha Do,
- Celeste Donato,
- Zheng Quan Toh,
- Rachel Higgins,
- Carolien Van de Sandt,
- Melissa M. Lemke,
- Christina Y. Lee,
- Suzanne K. Shoffner,
- Katie L. Flanagan,
- Kelly B. Arnold,
- Francesca L. Mordant,
- Kim Mulholland,
- Julie Bines,
- Kate Dohle,
- Daniel G. Pellicci,
- Nigel Curtis,
- Sarah McNab,
- Andrew Steer,
- Richard Saffery,
- Kanta Subbarao,
- Amy W. Chung,
- Katherine Kedzierska,
- David P. Burgner,
- Nigel W. Crawford
Affiliations
- Shidan Tosif
- Department of Paediatrics, The University of Melbourne
- Melanie R. Neeland
- Department of Paediatrics, The University of Melbourne
- Philip Sutton
- Department of Paediatrics, The University of Melbourne
- Paul V. Licciardi
- Department of Paediatrics, The University of Melbourne
- Sohinee Sarkar
- Department of Paediatrics, The University of Melbourne
- Kevin J. Selva
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Lien Anh Ha Do
- Department of Paediatrics, The University of Melbourne
- Celeste Donato
- Department of Paediatrics, The University of Melbourne
- Zheng Quan Toh
- Department of Paediatrics, The University of Melbourne
- Rachel Higgins
- Infection and Immunity, Murdoch Children’s Research Institute
- Carolien Van de Sandt
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Melissa M. Lemke
- Department of Biomedical Engineering, University of Michigan
- Christina Y. Lee
- Department of Biomedical Engineering, University of Michigan
- Suzanne K. Shoffner
- Department of Biomedical Engineering, University of Michigan
- Katie L. Flanagan
- Department of Infectious Diseases, Launceston General Hospital
- Kelly B. Arnold
- Department of Biomedical Engineering, University of Michigan
- Francesca L. Mordant
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Kim Mulholland
- Department of Paediatrics, The University of Melbourne
- Julie Bines
- Department of Paediatrics, The University of Melbourne
- Kate Dohle
- Infection and Immunity, Murdoch Children’s Research Institute
- Daniel G. Pellicci
- Department of Paediatrics, The University of Melbourne
- Nigel Curtis
- Department of Paediatrics, The University of Melbourne
- Sarah McNab
- Department of Paediatrics, The University of Melbourne
- Andrew Steer
- Department of Paediatrics, The University of Melbourne
- Richard Saffery
- Department of Paediatrics, The University of Melbourne
- Kanta Subbarao
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Amy W. Chung
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Katherine Kedzierska
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- David P. Burgner
- Department of Paediatrics, The University of Melbourne
- Nigel W. Crawford
- Department of Paediatrics, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-020-19545-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
Children with SARS-CoV-2 infection are more likely to have mild symptoms and may be asymptomatic, but underlying reasons remain unclear. Here, the authors show cellular, cytokine and antibody response to SARS-CoV-2 infection in three children who repeatedly tested negative for the virus by PCR, despite high exposure in the household.
