Nature Communications (Nov 2020)

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

  • Shidan Tosif,
  • Melanie R. Neeland,
  • Philip Sutton,
  • Paul V. Licciardi,
  • Sohinee Sarkar,
  • Kevin J. Selva,
  • Lien Anh Ha Do,
  • Celeste Donato,
  • Zheng Quan Toh,
  • Rachel Higgins,
  • Carolien Van de Sandt,
  • Melissa M. Lemke,
  • Christina Y. Lee,
  • Suzanne K. Shoffner,
  • Katie L. Flanagan,
  • Kelly B. Arnold,
  • Francesca L. Mordant,
  • Kim Mulholland,
  • Julie Bines,
  • Kate Dohle,
  • Daniel G. Pellicci,
  • Nigel Curtis,
  • Sarah McNab,
  • Andrew Steer,
  • Richard Saffery,
  • Kanta Subbarao,
  • Amy W. Chung,
  • Katherine Kedzierska,
  • David P. Burgner,
  • Nigel W. Crawford

DOI
https://doi.org/10.1038/s41467-020-19545-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Children with SARS-CoV-2 infection are more likely to have mild symptoms and may be asymptomatic, but underlying reasons remain unclear. Here, the authors show cellular, cytokine and antibody response to SARS-CoV-2 infection in three children who repeatedly tested negative for the virus by PCR, despite high exposure in the household.