Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2

A. Alfaro; M. Doan; J. Finke; M. Galdes; M. Zohdy

doi:10.1533/abbi.2006.0038

Applied Bionics and Biomechanics (Jan 2006)

Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2

A. Alfaro,
M. Doan,
J. Finke,
M. Galdes,
M. Zohdy

Affiliations

A. Alfaro: Mechanical Engineering Department, Oakland University, Rochester, Rochester, MI, USA
M. Doan: Statistics and Biology Department, Human Biology Department, Michigan State University, East Lansing, MI, USA
J. Finke: Chemistry Department, Oakland University, Rochester, MI, USA
M. Galdes: Materials Science and Engineering Department, Michigan State University, East Lansing, MI, USA
M. Zohdy: Electrical and Computer Engineering Department, Oakland University, Rochester, MI, USA

DOI: https://doi.org/10.1533/abbi.2006.0038
Journal volume & issue: Vol. 3, no. 4
pp. 263 – 271

Abstract

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Determining the method by which a protein thermodynamically folds and unfolds in three-dimension is one of the most complex and least understood problems in modern biochemistry. Misfolded proteins have been recently linked to diseases including Amyotrophic Lateral Sclerosis and Alzheimer's disease. Because of the large number of parameters involved in defining the tertiary structure of proteins, based on free energy global minimisation, we have developed a new Divide and Conquer (DAC) Extended Genetic Algorithm. The approach was applied to explore and verify the energy landscape of protein chymotrypsin inhibitor-2.

Published in Applied Bionics and Biomechanics

ISSN: 1176-2322 (Print); 1754-2103 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Biology (General)
Website: https://onlinelibrary.wiley.com/journal/9309

About the journal