Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development

Jiaojiao Wang; Xinyan Xie; Hang Li; Qiyue Zheng; Yun Chen; Wenjie Chen; Yajun Chen; Jieyu He; Qiong Lu

iScience (Apr 2024)

Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development

Jiaojiao Wang,
Xinyan Xie,
Hang Li,
Qiyue Zheng,
Yun Chen,
Wenjie Chen,
Yajun Chen,
Jieyu He,
Qiong Lu

Affiliations

Jiaojiao Wang: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China
Xinyan Xie: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China
Hang Li: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China
Qiyue Zheng: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China
Yun Chen: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China
Wenjie Chen: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China
Yajun Chen: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China
Jieyu He: Department of Geriatrics, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, P.R. China
Qiong Lu: Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, P.R. China; Corresponding author

Journal volume & issue: Vol. 27, no. 4
p. 109608

Abstract

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Summary: Osteoporosis has gradually become a major public health problem. Further elucidation of the pathophysiological mechanisms that induce osteoporosis and identification of more effective therapeutic targets will have important clinical significance. Experiments in vitro on bone marrow stem cells (BMSCs) subjected to osteogenic and adipogenic differentiation and in vivo on surgical bilateral ovariectomy (OVX) mouse models revealed that exosomes of vascular endothelial cells (EC-EXOs) can promote osteogenic differentiation of BMSCs and inhibit BMSC adipogenic differentiation through miR-3p-975_4191. Both miR-3p-975_4191 and curcumin can target tumor necrosis factor (TNF) and act synergistically to regulate BMSCs fate differentiation and delay the progression of osteoporosis. Our findings suggest that EC-EXOs may exert a synergistic effect with curcumin in reversing the progression of osteoporosis by targeting TNF via miR-3p-975_4191. Our study may provide therapeutic options and potential therapeutic targets for osteoporosis and thus has important clinical implications.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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