Nature Communications (Oct 2020)

Stress-induced RNA–chromatin interactions promote endothelial dysfunction

  • Riccardo Calandrelli,
  • Lixia Xu,
  • Yingjun Luo,
  • Weixin Wu,
  • Xiaochen Fan,
  • Tri Nguyen,
  • Chien-Ju Chen,
  • Kiran Sriram,
  • Xiaofang Tang,
  • Andrew B. Burns,
  • Rama Natarajan,
  • Zhen Bouman Chen,
  • Sheng Zhong

DOI
https://doi.org/10.1038/s41467-020-18957-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Global interaction of chromatin-associated RNAs and DNA can be identified in situ. Here the authors report the genome-wide increase of interchromosomal RNA-DNA interactions and demonstrate the importance of such RNA-DNA contacts exemplified by LINC00607 RNA and SERPINE1 gene’s super enhancer in dysfunctional endothelial cell models.