Nature Communications (Nov 2022)

Inflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes

  • Hamid Bolouri,
  • Rhonda E. Ries,
  • Alice E. Wiedeman,
  • Tiffany Hylkema,
  • Sheila Scheiding,
  • Vivian H. Gersuk,
  • Kimberly O’Brien,
  • Quynh-Anh Nguyen,
  • Jenny L. Smith,
  • S. Alice Long,
  • Soheil Meshinchi

DOI
https://doi.org/10.1038/s41467-022-34965-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

IL6 expression in the bone marrow is associated with reduced survival in paediatric AML. Here, the authors used RNA-seq to identify treatment resistance-associated co-occurring inflammatory signalling in leukemic cells.