Nature Communications (Jul 2021)
Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
- Franziska R. Traube,
- Dilara Özdemir,
- Hanife Sahin,
- Constanze Scheel,
- Andrea F. Glück,
- Anna S. Geserich,
- Sabine Oganesian,
- Sarantos Kostidis,
- Katharina Iwan,
- René Rahimoff,
- Grazia Giorgio,
- Markus Müller,
- Fabio Spada,
- Martin Biel,
- Jürgen Cox,
- Martin Giera,
- Stylianos Michalakis,
- Thomas Carell
Affiliations
- Franziska R. Traube
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Dilara Özdemir
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Hanife Sahin
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Constanze Scheel
- Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians-Universität München
- Andrea F. Glück
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Anna S. Geserich
- Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians-Universität München
- Sabine Oganesian
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Sarantos Kostidis
- Leiden University Medical Center, Center for Proteomics and Metabolomics
- Katharina Iwan
- Department of Chemistry, Ludwig-Maximilians-Universität München
- René Rahimoff
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Grazia Giorgio
- Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians-Universität München
- Markus Müller
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Fabio Spada
- Department of Chemistry, Ludwig-Maximilians-Universität München
- Martin Biel
- Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians-Universität München
- Jürgen Cox
- Computational Systems Biochemistry, Max Planck Institute of Biochemistry
- Martin Giera
- Leiden University Medical Center, Center for Proteomics and Metabolomics
- Stylianos Michalakis
- Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians-Universität München
- Thomas Carell
- Department of Chemistry, Ludwig-Maximilians-Universität München
- DOI
- https://doi.org/10.1038/s41467-021-24353-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.
