Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study

Abstract

Jianxin Chen,1 Junhui Wang,2 Qinhong Zheng,1 Meiling Weng,1 Xilin Wu1 1Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China; 2Department of Radiation Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of ChinaCorrespondence: Xilin WuDepartment of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of ChinaEmail [email protected]: Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rate and long-term survival for patients treated with this therapy remained unsatisfied. Herein, we present a case with lung adenocarcinoma accompanied with symptomatic brain metastasis who achieved radiologic complete response after receiving combined therapy including stereotactic body radiation therapy, anti-angiogenesis, and chemotherapy. He has achieved a duration of disease-free survival of thirty-six months, and is still in extension.Keywords: complete response, lung adenocarcinoma, brain metastasis, systematic therapy

Keywords

• complete response
• lung adenocarcinoma
• brain metastasis
• systematic therapy