Nature Communications (Nov 2017)

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

  • Matthias Rübsam,
  • Aaron F. Mertz,
  • Akiharu Kubo,
  • Susanna Marg,
  • Christian Jüngst,
  • Gladiola Goranci-Buzhala,
  • Astrid C. Schauss,
  • Valerie Horsley,
  • Eric R. Dufresne,
  • Markus Moser,
  • Wolfgang Ziegler,
  • Masayuki Amagai,
  • Sara A. Wickström,
  • Carien M. Niessen

DOI
https://doi.org/10.1038/s41467-017-01170-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

Read online

In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the granular layer 2.