Frontiers in Cell and Developmental Biology (Jul 2022)

Toll-Like Receptor 4 Signaling in the Trabecular Meshwork

  • Philip Mzyk,
  • Humberto Hernandez,
  • Thanh Le,
  • Jose Ricardo Ramirez,
  • Colleen M. McDowell

DOI
https://doi.org/10.3389/fcell.2022.936115
Journal volume & issue
Vol. 10

Abstract

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Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is signaling pathway in augmenting the effects of transforming growth factor beta-2 (TGFβ2) and downstream extracellular matrix production. In this review, we examine the role of TLR4 signaling in the trabecular meshwork and the interplay between endogenous activators of TLR4 (damage-associated molecular patterns (DAMPs)), extracellular matrix (ECM), and the effect on intraocular pressure

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