Development of Synergetic Combinations of a Novel Apoptosis Inducer with AKT and Hsp90 Selective Inhibitors Targeting Hormone-Sensitive and Hormone-Resistant Breast Cancer Cells
Diana I. Salnikova,
Stepan K. Krymov,
Danila V. Sorokin,
Fedor B. Bogdanov,
Olga E. Andreeva,
Alvina I. Khamidullina,
Andrey E. Shchekotikhin,
Alexander M. Scherbakov
Affiliations
Diana I. Salnikova
Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 24, 115522 Moscow, Russia
Stepan K. Krymov
Gause Institute of New Antibiotics, B. Pirogovskaya Street 11, 119021 Moscow, Russia
Danila V. Sorokin
Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 24, 115522 Moscow, Russia
Fedor B. Bogdanov
Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 24, 115522 Moscow, Russia
Olga E. Andreeva
Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 24, 115522 Moscow, Russia
Alvina I. Khamidullina
Laboratory of Molecular Oncobiology, Institute of Gene Biology, Russian Academy of Sciences, Vavilova Street 34/5, 119334 Moscow, Russia
Andrey E. Shchekotikhin
Gause Institute of New Antibiotics, B. Pirogovskaya Street 11, 119021 Moscow, Russia
Alexander M. Scherbakov
Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 24, 115522 Moscow, Russia
Introduction: The design and development of antitumor compounds based on an isatin core led to the synthesis of 1-substituted isatin-5-sulfonamides with potent antiproliferative activity [...]
