Molecules (Apr 2020)

Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of <i>Anvillea garcinii</i>

  • Shagufta Perveen,
  • Jawaher Alqahtani,
  • Raha Orfali,
  • Hanan Y. Aati,
  • Areej M. Al-Taweel,
  • Taghreed A. Ibrahim,
  • Afsar Khan,
  • Hasan S. Yusufoglu,
  • Maged S. Abdel-Kader,
  • Orazio Taglialatela-Scafati

DOI
https://doi.org/10.3390/molecules25071730
Journal volume & issue
Vol. 25, no. 7
p. 1730

Abstract

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Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity.

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