Nature Communications (Jan 2021)
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma
- Silvia Pomella,
- Prethish Sreenivas,
- Berkley E. Gryder,
- Long Wang,
- David Milewski,
- Matteo Cassandri,
- Kunal Baxi,
- Nicole R. Hensch,
- Elena Carcarino,
- Young Song,
- Hsien-Chao Chou,
- Marielle E. Yohe,
- Benjamin Z. Stanton,
- Bruno Amadio,
- Ignazio Caruana,
- Cristiano De Stefanis,
- Rita De Vito,
- Franco Locatelli,
- Yidong Chen,
- Eleanor Y. Chen,
- Peter Houghton,
- Javed Khan,
- Rossella Rota,
- Myron S. Ignatius
Affiliations
- Silvia Pomella
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS
- Prethish Sreenivas
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- Berkley E. Gryder
- Genetics Branch, NCI, NIH
- Long Wang
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- David Milewski
- Genetics Branch, NCI, NIH
- Matteo Cassandri
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS
- Kunal Baxi
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- Nicole R. Hensch
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- Elena Carcarino
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS
- Young Song
- Genetics Branch, NCI, NIH
- Hsien-Chao Chou
- Genetics Branch, NCI, NIH
- Marielle E. Yohe
- Genetics Branch, NCI, NIH
- Benjamin Z. Stanton
- Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University
- Bruno Amadio
- SAFU Laboratory, Translational Research Area, Regina Elena National Cancer Institute
- Ignazio Caruana
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS
- Cristiano De Stefanis
- Histology-Core Facility, Bambino Gesu’ Children’s Hospital, IRCCS
- Rita De Vito
- Department of Pathology Unit, Department of Laboratories, Bambino Gesu’ Children’s Hospital, IRCCS
- Franco Locatelli
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS
- Yidong Chen
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- Eleanor Y. Chen
- Department of Pathology, University of Washington
- Peter Houghton
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- Javed Khan
- Genetics Branch, NCI, NIH
- Rossella Rota
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS
- Myron S. Ignatius
- Greehey Children’s Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center
- DOI
- https://doi.org/10.1038/s41467-020-20386-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super enhancers, binds to MYOD target enhancers, and arrests differentiation.
