2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma

Peifeng Wang; Yang Du; Xingyang Zhao; Yueyang Hu; Tianjun Zhou; Xiaolong Liang; Chihua Fang; Jie Tian

Materials & Design (Aug 2023)

2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma

Peifeng Wang,
Yang Du,
Xingyang Zhao,
Yueyang Hu,
Tianjun Zhou,
Xiaolong Liang,
Chihua Fang,
Jie Tian

Affiliations

Peifeng Wang: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; CAS Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Chinese Academy of Sciences Institute of Automation, Beijing 100190, China; Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510280, China
Yang Du: CAS Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Chinese Academy of Sciences Institute of Automation, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100080, China
Xingyang Zhao: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510280, China
Yueyang Hu: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510280, China
Tianjun Zhou: Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Xiaolong Liang: Department of Ultrasound, Peking University Third Hospital, Beijing 100191, China; Corresponding authors.
Chihua Fang: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China; Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510280, China; Corresponding authors.
Jie Tian: CAS Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Chinese Academy of Sciences Institute of Automation, Beijing 100190, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China; Corresponding authors.

Journal volume & issue: Vol. 232
p. 112137

Abstract

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Hepatocellular carcinoma is a common and highly malignant disease. As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug. Based on this, a multifunctional mesoporous polydopamine nanoprobe 2Me-SPIO-CY5.5@AAZ-MPDA with a mesoporous frame loaded 2-Methoxyestradiol, Superparamagnetic Iron Oxide Nanoparticles and the near-infrared dye cyanine 5.5, conjugated with hypoxia Hepatocellular carcinoma-specific targeting molecule of sulfonamides acetazolamide, is fabricated for hypoxic region targeting, sorafenib resistance reversion and photothermal therapy of Hepatocellular carcinoma. In addition, the magnetic resonance imaging/fluorescence/photoacoustic tri-modal imaging ability enables the tracing of the nanoprobes and monitoring the treatment procedure in vivo, providing a new methods of imaging-guided Hepatocellular carcinoma synergic treatment which improves the long-term therapeutic effects of sorafenib.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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