Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase

Affiliations

Tatsuya Kubota: Department of Applied Molecular Chemistry, Graduate School of Industrial Technology, Nihon University
Erika Kurihara: Department of Biomolecular Science, Graduate School of Science, Toho University
Kazuya Watanabe: Department of Applied Molecular Chemistry, Graduate School of Industrial Technology, Nihon University
Kohei Ogata: Department of Biomolecular Science, Graduate School of Science, Toho University
Ryosuke Kaneko: Department of Biomolecular Science, Graduate School of Science, Toho University
Masaru Goto: Department of Biomolecular Science, Graduate School of Science, Toho University
Toshihisa Ohshima: Department of Biomedical Engineering, Osaka Institute of Technology
Kazuaki Yoshimune: Department of Applied Molecular Chemistry, Graduate School of Industrial Technology, Nihon University

Abstract

Heat-induced maturation of homoserine dehydrogenase from a hyperthermophilic archaeon requires conformational changes within the catalytic region.