Memorias do Instituto Oswaldo Cruz (May 2013)

Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

  • Camila Marx,
  • Tatiana Schaffer Gregianini,
  • Fernanda Kieling Moreira Lehmann,
  • Vagner Ricardo Lunge,
  • Silvia de Carli,
  • Bibiana Paula Dambros,
  • Gabriela Luchiari Tumioto,
  • Claudete Seadi,
  • Andre Salvador Kazantzi Fonseca,
  • Nilo Ikuta

DOI
https://doi.org/10.1590/S0074-02762013000300021
Journal volume & issue
Vol. 108, no. 3
pp. 392 – 394

Abstract

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The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

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