Nature Communications (Sep 2019)
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
Abstract
The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.