Nature Communications (Sep 2019)

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

  • F. Zhang,
  • N. N. Parayath,
  • C. I. Ene,
  • S. B. Stephan,
  • A. L. Koehne,
  • M. E. Coon,
  • E. C. Holland,
  • M. T. Stephan

DOI
https://doi.org/10.1038/s41467-019-11911-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.