Biological window excited up-conversion persistent luminescence nanoparticles for bioimaging and photodynamic therapy

Lin Liu; Kaiyan Huang; Xianggui Yin; Jinyuan Wang; Yan Gao; Junpeng Shi; Fangrong Zhang; Xia Sun; Chaohui Zheng

Journal of Saudi Chemical Society (Jul 2024)

Biological window excited up-conversion persistent luminescence nanoparticles for bioimaging and photodynamic therapy

Lin Liu,
Kaiyan Huang,
Xianggui Yin,
Jinyuan Wang,
Yan Gao,
Junpeng Shi,
Fangrong Zhang,
Xia Sun,
Chaohui Zheng

Affiliations

Lin Liu: The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Kaiyan Huang: The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
Xianggui Yin: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Jinyuan Wang: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Yan Gao: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Junpeng Shi: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou 350108, China
Fangrong Zhang: Key Laboratory of Gastrointestinal Cancer, Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China; Corresponding authors.
Xia Sun: Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou 350108, China; Corresponding authors.
Chaohui Zheng: The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; Corresponding authors.

Journal volume & issue: Vol. 28, no. 4
p. 101893

Abstract

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Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have inherent advantages for high-sensitivity bioimaging due to the separation of excitation and emission light. However, the single-wavelength emission of NIR PLNPs for bioimaging limits their use in photodynamic therapy (PDT). Herein, a biological window excited up-conversion (UC) PLNPs, Zn3Ga2SnO8:Cr3+,Yb3+,Ho3+ (ZGS), was reported for bioimaging and PDT. ZGS exhibits NIR persistent luminescence (PersL) after red LED excitation and visible UCL under 980 nm excitation. The NIR PersL is designed for in vivo bioimaging; the visible UCL is used to activate photosensitizer (PS) to generate reactive oxygen species (ROS) for PDT. The dual-functional ZGS with UCL and PersL provides an effective method for bioimaging and PDT, which is expected to further promote the application of PLNPs in the integration of efficient diagnosis and treatment.

Published in Journal of Saudi Chemical Society

ISSN: 1319-6103 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/journal-of-saudi-chemical-society/

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