Nature Communications (Jun 2022)
Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation
- Shengnan Liu,
- Siyi Shen,
- Ying Yan,
- Chao Sun,
- Zhiqiang Lu,
- Hua Feng,
- Yiruo Ma,
- Zhili Tang,
- Jing Yu,
- Yuting Wu,
- Balázs Gereben,
- Petra Mohácsik,
- Csaba Fekete,
- Xiaoyun Feng,
- Feixiang Yuan,
- Feifan Guo,
- Cheng Hu,
- Mengle Shao,
- Xin Gao,
- Lin Zhao,
- Yuying Li,
- Jingjing Jiang,
- Hao Ying
Affiliations
- Shengnan Liu
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Siyi Shen
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Ying Yan
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Chao Sun
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zhiqiang Lu
- Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University
- Hua Feng
- Omics Core, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
- Yiruo Ma
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zhili Tang
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Jing Yu
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yuting Wu
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Balázs Gereben
- Laboratory of Molecular Cell Metabolism, Institute of Experimental Medicine
- Petra Mohácsik
- Laboratory of Molecular Cell Metabolism, Institute of Experimental Medicine
- Csaba Fekete
- Laboratory of Integrative Neuroendocrinology, Institute of Experimental Medicine
- Xiaoyun Feng
- Department of Endocrinology and Metabolism, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University
- Feixiang Yuan
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Feifan Guo
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Cheng Hu
- Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Mengle Shao
- The Center for Microbes, Development and Health, Institute Pasteur of Shanghai, Chinese Academy of Sciences
- Xin Gao
- Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University
- Lin Zhao
- Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University
- Yuying Li
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Jingjing Jiang
- Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University
- Hao Ying
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- DOI
- https://doi.org/10.1038/s41467-022-31154-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Thyroid hormone (TH) action regulates brown adipose tissue thermogenic capacity through incompletely understood mechanisms. Here the authors report that T3, the active form of TH, increases thermogenic capacity via thyroid hormone receptor α-mediated hyperplasia of brown adipose tissue adipocyte progenitor cells.
