Nature Communications (May 2023)
A biodegradable, flexible photonic patch for in vivo phototherapy
- Kaicheng Deng,
- Yao Tang,
- Yan Xiao,
- Danni Zhong,
- Hua Zhang,
- Wen Fang,
- Liyin Shen,
- Zhaochuang Wang,
- Jiazhen Pan,
- Yuwen Lu,
- Changming Chen,
- Yun Gao,
- Qiao Jin,
- Lenan Zhuang,
- Hao Wan,
- Liujing Zhuang,
- Ping Wang,
- Junfeng Zhai,
- Tanchen Ren,
- Qiaoling Hu,
- Meidong Lang,
- Yue Zhang,
- Huanan Wang,
- Min Zhou,
- Changyou Gao,
- Lei Zhang,
- Yang Zhu
Affiliations
- Kaicheng Deng
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Yao Tang
- Research Center for Humanoid Sensing, Zhejiang Lab
- Yan Xiao
- Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
- Danni Zhong
- Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), School of Medicine, Zhejiang University
- Hua Zhang
- College of Animal Sciences, Zhejiang University
- Wen Fang
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Liyin Shen
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Zhaochuang Wang
- Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
- Jiazhen Pan
- College of Animal Sciences, Zhejiang University
- Yuwen Lu
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Changming Chen
- Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University
- Yun Gao
- College of Animal Sciences, Zhejiang University
- Qiao Jin
- College of Animal Sciences, Zhejiang University
- Lenan Zhuang
- College of Animal Sciences, Zhejiang University
- Hao Wan
- Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University
- Liujing Zhuang
- Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University
- Ping Wang
- Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University
- Junfeng Zhai
- Institute of Plant Quarantine, Chinese Academy of Inspection and Quarantine
- Tanchen Ren
- Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, Zhejiang University
- Qiaoling Hu
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Meidong Lang
- Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
- Yue Zhang
- San Francisco Veterans Affairs Medical Center
- Huanan Wang
- College of Animal Sciences, Zhejiang University
- Min Zhou
- State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University
- Changyou Gao
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Lei Zhang
- Research Center for Humanoid Sensing, Zhejiang Lab
- Yang Zhu
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- DOI
- https://doi.org/10.1038/s41467-023-38554-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Abstract Diagnostic and therapeutic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photonic device called iCarP with a micrometer scale air gap between a refractive polyester patch and the embedded removable tapered optical fiber. ICarP combines the advantages of light diffraction by the tapered optical fiber, dual refractions in the air gap, and reflection inside the patch to obtain a bulb-like illumination, guiding light towards target tissue. We show that iCarP achieves large area, high intensity, wide spectrum, continuous or pulsatile, deeply penetrating illumination without puncturing the target tissues and demonstrate that it supports phototherapies with different photosensitizers. We find that the photonic device is compatible with thoracoscopy-based minimally invasive implantation onto beating hearts. These initial results show that iCarP could be a safe, precise and widely applicable device suitable for internal organs and tissue illumination and associated diagnosis and therapy.
