Journal of Clinical Medicine (Feb 2023)
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease
- Diego Santos-García,
- Ariadna Laguna,
- Jorge Hernández-Vara,
- Teresa de Deus Fonticoba,
- Carlos Cores Bartolomé,
- Maria J. Feal Painceiras,
- Maria Cristina Íñiguez-Alvarado,
- Iago García Díaz,
- Silvia Jesús,
- Maria Teresa Boungiorno,
- Lluís Planellas,
- Marina Cosgaya,
- Juan García Caldentey,
- Nuria Caballol,
- Ines Legarda,
- Iria Cabo,
- Lydia López Manzanares,
- Isabel González Aramburu,
- Maria A. Ávila Rivera,
- Víctor Gómez Mayordomo,
- Víctor Nogueira,
- Víctor Puente,
- Julio Dotor García-Soto,
- Carmen Borrué,
- Berta Solano Vila,
- María Álvarez Sauco,
- Lydia Vela,
- Sonia Escalante,
- Esther Cubo,
- Francisco Carrillo Padilla,
- Juan C. Martínez Castrillo,
- Pilar Sánchez Alonso,
- Maria G. Alonso Losada,
- Nuria López Ariztegui,
- Itziar Gastón,
- Jaime Kulisevsky,
- Manuel Menéndez González,
- Manuel Seijo,
- Javier Rúiz Martínez,
- Caridad Valero,
- Mónica Kurtis,
- Jessica González Ardura,
- Ruben Alonso Redondo,
- Carlos Ordás,
- Luis M. López Díaz,
- Darrian McAfee,
- Pablo Martinez-Martin,
- Pablo Mir,
- on behalf of the COPPADIS Study Group
Affiliations
- Diego Santos-García
- Department of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, Spain
- Ariadna Laguna
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR), 08035 Barcelona, Spain
- Jorge Hernández-Vara
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR), 08035 Barcelona, Spain
- Teresa de Deus Fonticoba
- CHUF, Complejo Hospitalario Universitario de Ferrol, 15405 Ferrol, Spain
- Carlos Cores Bartolomé
- Department of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, Spain
- Maria J. Feal Painceiras
- Department of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, Spain
- Maria Cristina Íñiguez-Alvarado
- Department of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, Spain
- Iago García Díaz
- Department of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, Spain
- Silvia Jesús
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, Spain
- Maria Teresa Boungiorno
- Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain
- Lluís Planellas
- Clínica del Pilar, 50006 Barcelona, Spain
- Marina Cosgaya
- Hospital Clínic de Barcelona, 08036 Barcelona, Spain
- Juan García Caldentey
- Centro Neurológico Oms 42, 07003 Palma de Mallorca, Spain
- Nuria Caballol
- Consorci Sanitari Integral, Hospital Moisés Broggi, 08970 Sant Joan Despí, Spain
- Ines Legarda
- Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain
- Iria Cabo
- Complejo Hospitalario Universitario de Pontevedra (CHOP), 36001 Pontevedra, Spain
- Lydia López Manzanares
- Hospital Universitario La Princesa, 28006 Madrid, Spain
- Isabel González Aramburu
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, Spain
- Maria A. Ávila Rivera
- Consorci Sanitari Integral, Hospital General de L’Hospitalet, L’Hospitalet de Llobregat, 08906 Barcelona, Spain
- Víctor Gómez Mayordomo
- Hospital Universitario Clínico San Carlos, 28040 Madrid, Spain
- Víctor Nogueira
- Hospital Da Costa, 27880 Burela, Spain
- Víctor Puente
- Hospital del Mar, 08003 Barcelona, Spain
- Julio Dotor García-Soto
- Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
- Carmen Borrué
- Hospital Infanta Sofía, 28702 Madrid, Spain
- Berta Solano Vila
- Institut d’Assistència Sanitària (IAS)–Institut Català de la Salut, 17190 Girona, Spain
- María Álvarez Sauco
- Hospital General Universitario de Elche, 03203 Elche, Spain
- Lydia Vela
- Fundación Hospital de Alcorcón, 28922 Madrid, Spain
- Sonia Escalante
- Hospital de Tortosa Verge de la Cinta (HTVC), 43500 Tortosa, Spain
- Esther Cubo
- Complejo Asistencial Universitario de Burgos, 09006 Burgos, Spain
- Francisco Carrillo Padilla
- Hospital Universitario de Canarias, 38320 San Cristóbal de la Laguna, Spain
- Juan C. Martínez Castrillo
- Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, Spain
- Pilar Sánchez Alonso
- Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain
- Maria G. Alonso Losada
- Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), 36312 Vigo, Spain
- Nuria López Ariztegui
- Complejo Hospitalario de Toledo, 45007 Toledo, Spain
- Itziar Gastón
- Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
- Jaime Kulisevsky
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, Spain
- Manuel Menéndez González
- Hospital Universitario Central de Asturias, 33011 Oviedo, Spain
- Manuel Seijo
- Complejo Hospitalario Universitario de Pontevedra (CHOP), 36001 Pontevedra, Spain
- Javier Rúiz Martínez
- Hospital Universitario Donostia, 20014 Donostia, Spain
- Caridad Valero
- Hospital Arnau de Vilanova, 25198 Valencia, Spain
- Mónica Kurtis
- Hospital Ruber Internacional, 28034 Madrid, Spain
- Jessica González Ardura
- Hospital de Cabueñes, 33394 Gijón, Spain
- Ruben Alonso Redondo
- Universitario Lucus Augusti (HULA), 27003 Lugo, Spain
- Carlos Ordás
- Hospital Rey Juan Carlos, 28933 Madrid, Spain
- Luis M. López Díaz
- Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), 36312 Vigo, Spain
- Darrian McAfee
- Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
- Pablo Martinez-Martin
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, Spain
- Pablo Mir
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, Spain
- on behalf of the COPPADIS Study Group
- DOI
- https://doi.org/10.3390/jcm12041329
- Journal volume & issue
-
Vol. 12,
no. 4
p. 1329
Abstract
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p p p p p p p p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
Keywords