Potential Strategies to Improve the Effectiveness of Drug Therapy by Changing Factors Related to Tumor Microenvironment

Dehong Cao; Xiaokaiti Naiyila; Xiaokaiti Naiyila; Jinze Li; Jinze Li; Yin Huang; Yin Huang; Zeyu Chen; Zeyu Chen; Bo Chen; Bo Chen; Jin Li; Jin Li; Jianbing Guo; Qiang Dong; Jianzhong Ai; Lu Yang; Liangren Liu; Qiang Wei

doi:10.3389/fcell.2021.705280

Frontiers in Cell and Developmental Biology (Aug 2021)

Potential Strategies to Improve the Effectiveness of Drug Therapy by Changing Factors Related to Tumor Microenvironment

Dehong Cao,
Xiaokaiti Naiyila,
Xiaokaiti Naiyila,
Jinze Li,
Jinze Li,
Yin Huang,
Yin Huang,
Zeyu Chen,
Zeyu Chen,
Bo Chen,
Bo Chen,
Jin Li,
Jin Li,
Jianbing Guo,
Qiang Dong,
Jianzhong Ai,
Lu Yang,
Liangren Liu,
Qiang Wei

Affiliations

Dehong Cao: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Xiaokaiti Naiyila: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Xiaokaiti Naiyila: West China School of Medicine, Sichuan University, Chengdu, China
Jinze Li: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Jinze Li: West China School of Medicine, Sichuan University, Chengdu, China
Yin Huang: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Yin Huang: West China School of Medicine, Sichuan University, Chengdu, China
Zeyu Chen: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Zeyu Chen: West China School of Medicine, Sichuan University, Chengdu, China
Bo Chen: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Bo Chen: West China School of Medicine, Sichuan University, Chengdu, China
Jin Li: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Jin Li: West China School of Medicine, Sichuan University, Chengdu, China
Jianbing Guo: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Qiang Dong: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Jianzhong Ai: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Lu Yang: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Liangren Liu: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
Qiang Wei: Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China

DOI: https://doi.org/10.3389/fcell.2021.705280
Journal volume & issue: Vol. 9

Abstract

Read online

A tumor microenvironment (TME) is composed of various cell types and extracellular components. It contains tumor cells and is nourished by a network of blood vessels. The TME not only plays a significant role in the occurrence, development, and metastasis of tumors but also has a far-reaching impact on the effect of therapeutics. Continuous interaction between tumor cells and the environment, which is mediated by their environment, may lead to drug resistance. In this review, we focus on the key cellular components of the TME and the potential strategies to improve the effectiveness of drug therapy by changing their related factors.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

About the journal

Abstract

Keywords