Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity

Xiao Yu; Yang Du; Chunmei Cai; Baowei Cai; Motao Zhu; Changsheng Xing; Peng Tan; Meng Lin; Jian Wu; Jian Li; Mingjun Wang; Helen Y. Wang; Xin-zhuan Su; Rong-Fu Wang

doi:10.1038/s41467-018-07384-7

Nature Communications (Nov 2018)

Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity

Xiao Yu,
Yang Du,
Chunmei Cai,
Baowei Cai,
Motao Zhu,
Changsheng Xing,
Peng Tan,
Meng Lin,
Jian Wu,
Jian Li,
Mingjun Wang,
Helen Y. Wang,
Xin-zhuan Su,
Rong-Fu Wang

Affiliations

Xiao Yu: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Yang Du: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Chunmei Cai: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Baowei Cai: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Motao Zhu: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Changsheng Xing: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Peng Tan: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Meng Lin: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Jian Wu: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jian Li: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University
Mingjun Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Helen Y. Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Xin-zhuan Su: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Rong-Fu Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute

DOI: https://doi.org/10.1038/s41467-018-07384-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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The inflammasome is an essential component of inflammatory processes and the host response to infection. Here the authors show that inflammasome activation modulates MyD88-IRF7 type I IFN signalling and anti-malaria immunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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