Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetylphenyl)carbamoyl]phenyl acetate

Abstract

2-[(4-Acetylphenyl)carbamoyl]phenyl acetate, C17H15NO4, has been synthesized and structurally characterized. In the structure, N—H...O hydrogen-bonding interactions form chains of molecules aligned along the [101] direction. The chains are linked by π–π and C—H...π interactions, forming a three dimensional network. The compound has been screened for in vitro anti-proliferative activity revealing considerable activity.

Keywords

• crystal structure
• aspirin derivative
• nci 60 cell line
• anti-proliferative activity