Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum
Ayush Noori,
Aziz M. Mezlini,
Bradley T. Hyman,
Alberto Serrano-Pozo,
Sudeshna Das
Affiliations
Ayush Noori
Harvard College, Cambridge, MA 02138, United States of America; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States of America; MIND Data Science Lab, Cambridge, MA 02139, United States of America; MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, United States of America
Aziz M. Mezlini
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States of America; MIND Data Science Lab, Cambridge, MA 02139, United States of America; MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, United States of America; Harvard Medical School, Boston, MA 02115, United States of America
Bradley T. Hyman
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States of America; MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, United States of America; Harvard Medical School, Boston, MA 02115, United States of America
Alberto Serrano-Pozo
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States of America; MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, United States of America; Harvard Medical School, Boston, MA 02115, United States of America; Corresponding authors.
Sudeshna Das
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States of America; MIND Data Science Lab, Cambridge, MA 02139, United States of America; MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, United States of America; Harvard Medical School, Boston, MA 02115, United States of America; Corresponding authors.
In Noori et al. [1], we hypothesized that there is a shared gene expression signature underlying neurodegenerative proteinopathies including Alzheimer's disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum. To test this hypothesis, we performed a systematic review and meta-analysis of 60 human central nervous system transcriptomic datasets in the public Gene Expression Omnibus and ArrayExpress repositories, comprising a total of 2,600 AD, LBD, and ALS-FTD patients and age-matched controls which passed our stringent quality control pipeline. Here, we provide the results of differential expression analyses with data quality reports for each of these 60 datasets. This atlas of differential expression across AD, LBD, and ALS-FTD may guide future work to elucidate the pathophysiological drivers of these individual diseases as well as the common substrate of neurodegeneration.
