Frontiers in Immunology (Dec 2021)

Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity

  • Theodore J. Kottom,
  • Theodore J. Kottom,
  • Eva M. Carmona,
  • Eva M. Carmona,
  • Andrew H. Limper,
  • Andrew H. Limper

DOI
https://doi.org/10.3389/fimmu.2021.798214
Journal volume & issue
Vol. 12

Abstract

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Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.

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