Journal of Clinical Medicine (Sep 2021)
The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children
- Małgorzata Mizerska-Wasiak,
- Agnieszka Such-Gruchot,
- Karolina Cichoń-Kawa,
- Agnieszka Turczyn,
- Jadwiga Małdyk,
- Monika Miklaszewska,
- Dorota Drożdż,
- Agnieszka Firszt-Adamczyk,
- Roman Stankiewicz,
- Agnieszka Rybi-Szumińska,
- Anna Wasilewska,
- Maria Szczepańska,
- Beata Bieniaś,
- Przemysław Sikora,
- Agnieszka Pukajło-Marczyk,
- Danuta Zwolińska,
- Monika Pawlak-Bratkowska,
- Marcin Tkaczyk,
- Jacek Zachwieja,
- Magdalena Drożyńska-Duklas,
- Aleksandra Żurowska,
- Katarzyna Gadomska-Prokop,
- Ryszard Grenda,
- Małgorzata Pańczyk-Tomaszewska
Affiliations
- Małgorzata Mizerska-Wasiak
- Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
- Agnieszka Such-Gruchot
- Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
- Karolina Cichoń-Kawa
- Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
- Agnieszka Turczyn
- Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
- Jadwiga Małdyk
- Department of Pathology, Medical University of Warsaw, 02-091 Warsaw, Poland
- Monika Miklaszewska
- Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, 30-663 Cracow, Poland
- Dorota Drożdż
- Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, 30-663 Cracow, Poland
- Agnieszka Firszt-Adamczyk
- Department of Pediatrics and Nephrology, Ludwik Rydygier Hospital, 87-100 Torun, Poland
- Roman Stankiewicz
- Department of Pediatrics and Nephrology, Ludwik Rydygier Hospital, 87-100 Torun, Poland
- Agnieszka Rybi-Szumińska
- Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-089 Bialystok, Poland
- Anna Wasilewska
- Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-089 Bialystok, Poland
- Maria Szczepańska
- Department of Pediatrics, SMDZ in Zabrze, Silesian Medical University, 41-808 Zabrze, Poland
- Beata Bieniaś
- Department of Pediatric Nephrology, Medical University of Lublin, 20-059 Lublin, Poland
- Przemysław Sikora
- Department of Pediatric Nephrology, Medical University of Lublin, 20-059 Lublin, Poland
- Agnieszka Pukajło-Marczyk
- Department of Pediatric Nephrology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Danuta Zwolińska
- Department of Pediatric Nephrology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Monika Pawlak-Bratkowska
- Department of Pediatrics, Immunology and Nephrology, Polish Mothers Memorial Hospital Research Institute, 93-338 Lodz, Poland
- Marcin Tkaczyk
- Department of Pediatrics, Immunology and Nephrology, Polish Mothers Memorial Hospital Research Institute, 93-338 Lodz, Poland
- Jacek Zachwieja
- Department of Pediatric Nephrology and Dialysis, Medical University of Poznan, 61-701 Poznan, Poland
- Magdalena Drożyńska-Duklas
- Department of Pediatrics, Nephrology and Hypertension, Medical University of Gdansk, 80-210 Gdansk, Poland
- Aleksandra Żurowska
- Department of Pediatrics, Nephrology and Hypertension, Medical University of Gdansk, 80-210 Gdansk, Poland
- Katarzyna Gadomska-Prokop
- Department of Nephrology, Kidney Transplantation and Hypertension, Children’s Memorial Health Institute, 04-730 Warsaw, Poland
- Ryszard Grenda
- Department of Nephrology, Kidney Transplantation and Hypertension, Children’s Memorial Health Institute, 04-730 Warsaw, Poland
- Małgorzata Pańczyk-Tomaszewska
- Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
- DOI
- https://doi.org/10.3390/jcm10194405
- Journal volume & issue
-
Vol. 10,
no. 19
p. 4405
Abstract
The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children.
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