Biomolecules
(Apr 2022)
COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
Viscardo P. Fabbri,
Mattia Riefolo,
Tiziana Lazzarotto,
Liliana Gabrielli,
Giovanna Cenacchi,
Carmine Gallo,
Raffaele Aspide,
Guido Frascaroli,
Rocco Liguori,
Raffaele Lodi,
Caterina Tonon,
Antonietta D’Errico,
Maria Pia Foschini
Affiliations
Viscardo P. Fabbri
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna, Italy
Mattia Riefolo
Department of Experimental, Diagnostic and Specialty Medicine, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy
Tiziana Lazzarotto
Department of Experimental, Diagnostic and Specialty Medicine, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy
Liliana Gabrielli
Operative Unit of Clinical Microbiology, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy
Giovanna Cenacchi
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna, Italy
Carmine Gallo
Unit of Anatomic Pathology, Department of Oncology, Bellaria Hospital, Via Altura 3, 40139 Bologna, Italy
Raffaele Aspide
Anesthesia and Neurointensive Care Unit, IRCCS Institute of Neurological Science of Bologna, Via Altura 3, 40139 Bologna, Italy
Guido Frascaroli
Intensive Unit Care, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy
Rocco Liguori
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna, Italy
Raffaele Lodi
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna, Italy
Caterina Tonon
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna, Italy
Antonietta D’Errico
Department of Experimental, Diagnostic and Specialty Medicine, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy
Maria Pia Foschini
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna, Italy
DOI
https://doi.org/10.3390/biom12050629
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
Neurological symptoms are increasingly recognized in SARS-CoV-2 infected individuals. However, the neuropathogenesis remains unclear and it is not possible to define a specific damage pattern due to brain virus infection. In the present study, 33 cases of brain autopsies performed during the first (February–April 2020) and the second/third (November 2020–April 2021) pandemic waves are described. In all the cases, SARS-CoV-2 RNA was searched. Pathological findings are described and compared with those presently published.
Keywords
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