Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib

André Fuchs; Hans-Martin Orth; Ulrich Germing; Mustafa Kondakci; Martha Holtfreter; Torsten Feldt; Björn Erik-Ole Jensen; Dieter Häussinger

International Journal of Infectious Diseases (Nov 2020)

Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib

André Fuchs,
Hans-Martin Orth,
Ulrich Germing,
Mustafa Kondakci,
Martha Holtfreter,
Torsten Feldt,
Björn Erik-Ole Jensen,
Dieter Häussinger

Affiliations

André Fuchs: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany
Hans-Martin Orth: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany
Ulrich Germing: Department of Hematology, Oncology and Clinical Immunology, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany
Mustafa Kondakci: Department of Hematology, Oncology and Clinical Immunology, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany
Martha Holtfreter: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany
Torsten Feldt: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany
Björn Erik-Ole Jensen: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany; Corresponding author at: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.
Dieter Häussinger: Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany

Journal volume & issue: Vol. 100
pp. 382 – 385

Abstract

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JAK/STAT signaling plays a major role in the pathogenesis of secondary hemophagocytic lymphohistiocytosis. This case report on a critically ill patient with secondary hemophagocytic lymphohistiocytosis due to falciparum malaria treated successfully with ruxolitinib, demonstrates that JAK1/2 inhibition might be a promising treatment option for severe cases.

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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